AK3L1

AK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AR7, 2BBW, 3NDP
Identifiers
Aliases	AK4, AK 4, AK3, AK3L1, AK3L2, adenylate kinase 4
External IDs	OMIM: 103030; MGI: 87979; HomoloGene: 100316; GeneCards: AK4; OMA:AK4 - orthologs
EC number	2.7.4.3
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.3 Start 65,147,549 bp End 65,232,145 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C6|4 46.84 cM Start 101,276,474 bp End 101,324,192 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla right ventricle pericardium kidney saphenous vein lactiferous duct internal globus pallidus liver nipple entorhinal cortex Top expressed in cumulus cell secondary oocyte kidney proximal tubule cerebellar vermis blastocyst subiculum endocardial cushion morula primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding nucleoside triphosphate adenylate kinase activity GTP binding phosphotransferase activity, phosphate group as acceptor kinase activity nucleobase-containing compound kinase activity adenylate kinase activity ATP binding nucleoside monophosphate kinase activity nucleoside diphosphate kinase activity protein binding Cellular component mitochondrial matrix mitochondrion Biological process nucleobase-containing small molecule interconversion phosphorylation nucleoside diphosphate phosphorylation brain development nucleoside triphosphate biosynthetic process liver development nucleobase-containing compound metabolic process nucleoside monophosphate phosphorylation AMP metabolic process ATP metabolic process GTP metabolic process ADP biosynthetic process regulation of oxidative phosphorylation cellular response to hypoxia regulation of ATP biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 205 11639 Ensembl ENSG00000162433 ENSMUSG00000028527 UniProt P27144 Q9WUR9 RefSeq (mRNA) NM_203464 NM_001005353 NM_013410 NM_001330616 NM_001177602 NM_001177604 NM_001177605 NM_009647 RefSeq (protein) NP_001005353 NP_001317545 NP_037542 NP_982289 NP_001171073 NP_001171075 NP_001171076 NP_033777 Location (UCSC) Chr 1: 65.15 – 65.23 Mb Chr 4: 101.28 – 101.32 Mb PubMed search
Wikidata
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Adenylate kinase isoenzyme 4, mitochondrial is an enzyme that in humans is encoded by the AK4 gene.

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. Expression of AK4 may regulate global cellular ATP levels and modulate the AMPK signaling pathway.

External links

• Human AK3 genome location and AK3 gene details page in the UCSC Genome Browser.
• Human AK4 genome location and AK4 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P27144 (Adenylate kinase 4, mitochondrial) at the PDBe-KB.

Further reading

• Povey S, Slaughter CA, Wilson DE, et al. (1976). "Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in man". Ann. Hum. Genet. 39 (4): 413–22. doi:10.1111/j.1469-1809.1976.tb00145.x. PMID 182062. S2CID 40660799.
• Xu G, O'Connell P, Stevens J, White R (1992). "Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene". Genomics. 13 (3): 537–42. doi:10.1016/0888-7543(92)90122-9. PMID 1639383.
• Robson EB, Meera Khan P (1983). "Report of the committee on the genetic constitution of chromosomes 7, 8, and 9. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping". Cytogenet. Cell Genet. 32 (1–4): 144–52. doi:10.1159/000131694. PMID 7140357.
• Nobumoto M, Yamada M, Song S, et al. (1998). "Mechanism of mitochondrial import of adenylate kinase isozymes". J. Biochem. 123 (1): 128–35. doi:10.1093/oxfordjournals.jbchem.a021899. PMID 9504419.
• Yoneda T, Sato M, Maeda M, Takagi H (1999). "Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase". Brain Res. Mol. Brain Res. 62 (2): 187–95. CiteSeerX 10.1.1.525.4121. doi:10.1016/S0169-328X(98)00249-6. PMID 9813319.
• Noma T, Adachi N, Nakazawa A (1999). "Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3". Biochem. Biophys. Res. Commun. 264 (3): 990–7. doi:10.1006/bbrc.1999.1616. PMID 10544043.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.